A survey on distribution and drug resistance of pathogens causing nosocomial infection in general intensive care unit
10.3969/j.issn.1008-9691.2015.04.012
- VernacularTitle:综合重症加强治疗病房医院感染的常见致病菌分析以及耐药性监测结果
- Author:
Haifeng LIU
;
Zhujiang ZHOU
;
Jingqing HU
;
Nina HUANG
;
Wenzhao CHEN
;
Ruiqiu ZHU
;
Jianhai LU
;
Yanhe CHEN
;
Jiahui MAI
;
Yongpeng SU
- Publication Type:Journal Article
- Keywords:
Intensive care unit;
Nosocomial infection;
Antibiotics;
Drug resistance
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2015;(4):382-385
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution and drug resistance of pathogens in intensive care unit (ICU) so as to provide scientific basis for antibiotic adoption and the prevention and control of nosocomial infections. Methods The various specimens collected from the patients admitted into ICU in the First People's Hospital of Shunde Affiliated to the South Medical University from January 2007 to December 2014 were used to isolate the pathogens that might cause nosocomial infections and retrospectively analyze their clinical distribution and drug resistance. Kirby-Bauer paper diffusion and minimal inhibitory concentration (MIC) methods were applied to test the drug sensitivity, and according to National Committee for Clinical Laboratory Standards/Clinical and Laboratory Standards Institute (NCCLS/CLSI) standard, the results were identified.Results The sputum was the major specimen source in ICU, accounting for 68.8%, followed by urine (12.4%) and blood (6.8%). All together 557 pathogens in ICU causing nosocomial infections were isolated of which there were 377 gram-negative (G-) bacilli (67.7%), 103 gram-positive (G+) cocci (18.5%), and 77 fungi (13.8%). Among G- bacilli, the top three wereAcinetobacter baumannii (34.5%), Klebsiella pneumonia (17.8%), andPseudomonas aeruginosa (13.0%). Beside carbapenem, the drug resistance rates of Acinetobacterbaumannii to other antibiotics were more than 40%. The main G+ coccus causing nosocomial infection wasSaphylococcus aureus (36.9%) in ICU. The drug resistance rates ofSaphylococcus aureus to penicillin, gentamicin and erythromycin were higher than 50%. In 77 fungus strains,Candida albicans was ranked the first, accounting for 41.6%.Conclusion The main infection site in ICU is primarily respiratory tract, the G- bacilli are the predominate pathogens, and the drug resistance to antibiotics found in this report is serious, so clinically, the antibiotics should be properly used to avoid the occurrence of pathogenic strain with drug tolerance.
