Association between IRF6 gene SNPs and non-syndromic cleft lip with or without cleft palate in Xinjiang Uyghur population
10.3969/j.issn.1001-3733.2015.04.011
- VernacularTitle:IRF6基因 SNPs 与新疆维吾尔族非综合征型唇腭裂相关性研究
- Author:
Ling WANG
;
Li GU
;
Wei AN
;
Moming ADILI
- Publication Type:Journal Article
- Keywords:
Non-syndromic cleft lip and palate;
Interferon regulatory factor;
Single nucleotide polymorphisms (SNPs);
Uyghur
- From:
Journal of Practical Stomatology
2015;(4):502-505
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the association between rs2235371,rs2013162,rs2235377 SNPs in interferon regulatory factor 6 (IRF6)gene and non-syndromic cleft lip with or without cleft palate(NSCL/P)in Xinjiang Uyghur population.Methods:100 Uyghur NSCL/P patients from Xinjiang were included in the case group and 60 Uyghur inpatients with upper respiratory tract infection were se-lected in the control group.Next,generation sequencing was used,DNA sequencing results were compared with the information on the genome database and genetic analysis were made.Results:There were no significant differences in the frequency distribution of both genotypes and alles when the cases were campared with the controls at the rs2235371,rs2013162 and rs2235377 loci(P >0.05). Above three loci were located in the same block,rs2235371 and rs2235377 loci presents the strong linkage disequilibrium(r2 =0.949, D'=0.974).Possible haplotypes were:CCT >CAT >TAC,and there was no significant difference between the cases and controls in haplotype distribution(P >0.05).Conclusion:Polymorphisms of rs2235371,rs2013162 and rs2235377 in IRF6 gene may be associ-ated with NSCL/P in Xinjiang Uygur people.
