The association between serum leptin level and periodontal parameters in patients with type 2 diabetes mel-litus and periodontitis

VernacularTitle:2型糖尿病牙周炎患者血清瘦素水平与牙周临床指标的相关性研究
Author: Zhiyun WU ; Xiuqiu GAO
Publication Type:Journal Article
Keywords: Leptin; Type 2 diabetes mellitus; Periodontitis; Periodontal parameters
From: Journal of Practical Stomatology 2015;(4):511-514
CountryChina
Language:Chinese
Abstract: Objective:To explore the association of serum leptin(LEP)level in patients of type 2 diabetes mellitus and periodontitis with clinical periodontal indexes.Methods:30 healthy subjects(group A),30 chronic periodontitis patients(group B)and 30 type 2 diabetic patients with chronic periodontitis(DMCP)(group C)were included.Probing depth(PD),attachment loss(AL),plaque index (PLI)and bleeding on probe(BOP)were examined.High performance liquid chromatography detection was used to determine the ex-pression of the fasting plasma glucose (FPG),glycated hemoglobin(HbA1c)in plasma samples.Serum level of LEP was measured by ELISA.Results:Levels of serum HbA1c,FPG and LEP in group C were significantly higher than those in group B and A(P <0.05);serum LEP in group B were significantly higher than those in group A(P <0.05).However,no virtual disparity was found in serum HbA1c and FPG between group A and B(P >0.05);The r values of plasma LEP level to PD,AL,PLI and BOP were 0.506,0.551, 0.519 and 0.582 respectively(P <0.05).Conclusion:The LEP level is elevated in patients with DMCP.Circulating LEP level is positively related to PD,AL,PLI and BOP.