Association between Adiponectin polymorphisms and nonalcoholic fatty liver disease in Han Chinese popu-lation in Qingdao
10.3969/j.issn.1006-5725.2015.09.011
- VernacularTitle:青岛地区汉族人群脂联素基因多态性与非酒精性脂肪性肝病的相关性
- Author:
Yuting CHENG
;
Man JIANG
;
Yongning XIN
;
Baiquan AN
;
Shiying XUAN
- Publication Type:Journal Article
- Keywords:
Fatty liver,non-alcoholic;
Adiponectin;
Gene polymorphisms
- From:
The Journal of Practical Medicine
2015;(9):1421-1424
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the Adiponectin rs266729 and rs2241766 gene polymorphisms and nonalcoholic fatty liver disease in the Han Chinese population residing in Qingdao. Methods Adiponectin rs266729 and rs2241766 gene polymorphisms were genotyped in patients with NAFLD (n = 336) and healthy controls (n = 280) using polymerase chain reaction (PCR). Serum lipid profiles and adiponectin levels were determined using biochemical methods. Statistical analyses were performed using Pearson Chi square test, logistic regression analysis, t test, linear regression analysis. Results We found a significant association between the Adiponectin rs266729 genotype frequencies and allele frequencies between NAFLD pa-tients and controls (χ2= 9.929, P = 0.007; χ2= 9.809, P = 0.002). After adjustment of confounding factor, the rs266729 G allele was associated with an increased risk of NAFLD compared to the C allele (OR = 1.410, 95%CI: 1.082-1.831, P = 0.008) No significant differences were found in the rs2241766 genotype frequencies and allele frequencies between NAFLD population and the controls (OR = 1.410, 95%CI: 1.082-1.831, P = 0.008). Conclusion The Han Chinese in Qingdao carrying the rs266729 G allele are at increased risk of NAFLD.
