The role of CXCR2 in the invasion and metastasis of head and neck squamous cell carcinoma

VernacularTitle:趋化因子受体 CXCR2参与头颈部鳞癌侵袭转移机制的实验研究
Author: Zongyao WANG ; Dong JI ; Jianwei LIU ; Yong QIAN
Publication Type:Journal Article
Keywords: Head and neck squamous cell carcinoma(HNSCC); CXCR2; Invasion; Metastases
From: Journal of Practical Stomatology 2015;(4):478-483
CountryChina
Language:Chinese
Abstract: Objective:To explore the role of CXCR2 in the invasion and metastasis of head and neck squamous cell carcinoma (HNSCC).Methods:The expression of CXCR2 in HNSCC tissues of 105 cases was detected by immunohistochemical staining,the correlation between CXCR2 expression and cervical lymph node metastases of HNSCC was analysed.Then,3 stable HNSCC cell lines with CXCR2 interference were established,the effects of CXCR2 silencing on cell migration and invasion were observed by in vitro tests.Results:CXCR2 was positively expressed in 51.43% of HNSCC specimens and was statistically associated with the cervical lymph node metastases of HNSCC.CXCR2 silencing markedly inhibited the migration and invasion of HNSCC cells in vitro.Conclu-sion:CXCR2 may play a key role in the invasion and metastases of HNSCC.