The role of CXCR2 in the invasion and metastasis of head and neck squamous cell carcinoma
10.3969/j.issn.1001-3733.2015.04.06
- VernacularTitle:趋化因子受体 CXCR2参与头颈部鳞癌侵袭转移机制的实验研究
- Author:
Zongyao WANG
;
Dong JI
;
Jianwei LIU
;
Yong QIAN
- Publication Type:Journal Article
- Keywords:
Head and neck squamous cell carcinoma(HNSCC);
CXCR2;
Invasion;
Metastases
- From:
Journal of Practical Stomatology
2015;(4):478-483
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of CXCR2 in the invasion and metastasis of head and neck squamous cell carcinoma (HNSCC).Methods:The expression of CXCR2 in HNSCC tissues of 105 cases was detected by immunohistochemical staining,the correlation between CXCR2 expression and cervical lymph node metastases of HNSCC was analysed.Then,3 stable HNSCC cell lines with CXCR2 interference were established,the effects of CXCR2 silencing on cell migration and invasion were observed by in vitro tests.Results:CXCR2 was positively expressed in 51.43% of HNSCC specimens and was statistically associated with the cervical lymph node metastases of HNSCC.CXCR2 silencing markedly inhibited the migration and invasion of HNSCC cells in vitro.Conclu-sion:CXCR2 may play a key role in the invasion and metastases of HNSCC.