Acupuncture following degradable cerebrovascular stent implantation: rehabilitation efficacy and stent biocompatibility
10.3969/j.issn.2095-4344.2015.21.019
- VernacularTitle:针刺对可降解脑血管支架材料置入后康复效果及生物相容性的影响
- Author:
Xiaohong LI
;
Heping YU
;
Wanqun CAO
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2015;19(21):3382-3386
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Intracranial and extracranial arterial stent implantation is the main therapy for cerebrovascular diseases, especialy for some patients who cannot tolerate surgical operation, but the postoperative rehabilitation and biocompatibility problems restrict the further development of the technology. OBJECTIVE:To explore the rehabilitation efficacy and biocompatibility of acupuncture after degradable cerebrovascular stent implantation. METHODS: A total of 70 patients with cerebral arterial stenosis aged 43-79 years were enroled, including 41 males and 29 females, who were al treated with drug-eluting stent implantation, carotid artery stent implantation in 31 cases, vertebral artery stent implantation in 21 cases, subclavian stent implantation in 5 cases, and middle cerebral artery stent implantation in 13 cases. After stent implantation, al the patients were randomly divided into two groups: control group with routine rehabilitation therapy and acupuncture group with routine rehabilitation therapy+electroacupuncture. After 3 months of treamtnet, neurologic impairment scores, Fugl-Meyer score for motor function, Barthel index, degree of stent stenosis, thromboxane A2, prostacyclin, thromboxane A2/ prostacyclin levels were detected. RESULTS AND CONCLUSION:At 3 months after treatment, the neurological impairment scores were significantly lower in the acupuncture group than the control group (P < 0.05), but the Fugl-Meyer score for motor function andBarthel index were higher in the control group (P < 0.05). After treatment, the thromboxane A2 and thromboxane A2/prostacyclin levels were significantly decreased in the two groups (P < 0.05), but the prostacyclin levels were increased than those before treatment (P < 0.05). In addition, there were no differences in the thromboxane A2, prostacyclin, thromboxane A2/prostacyclin levels between the two groups. Compared with the control group, the rate of restenosis was significantly lower in the acupuncture group (P < 0.05), and there were no significant difference in the reference vessel diameter, blood vessel stent diameter, decreased vessel diameter index, re-intervention rate between the two groups (P > 0.05). Taken together, acupuncture can promote the rehabilitation efficacy folowing degradable cerebrovascular stent implantation, reduce the incidence of restenosis, and show good biocompatibility.
