Experimental vascular dementia rats model of real-time gait behavior analysis
10.3969/j.issn.1671.7856.2015.001.011
- VernacularTitle:实验性血管性痴呆大鼠模型的实时步态行为分析
- Author:
Yalan GUAN
;
Shifen DONG
;
Shengwei ZHANG
;
Jianning SUN
;
Zhenquan LIU
- Publication Type:Journal Article
- Keywords:
Vascular dementia;
Rat model;
Gait behavior
- From:
Chinese Journal of Comparative Medicine
2015;(1):59-65
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish experimental vascular dementia rat model and evaluate gait behavior . Methods Vascular dementia rat model induced by bilateral carotid artery ligation methods , 50 days for real-time gait behavioral training and testing after surgery .Results Compared with the sham group , Experimental vascular dementia model rats had 19 gait indicators appeared significantly statistical difference , Animal model gait abnormal behavior is mainly reflected in the forelimb step width increased (P <0.05), each foot walk cycle extension (P <0.05), Each foot stance time increased (P <0.05, P <0.01), and the swing time shortened (P <0.05), Homologous coupling shortened (P<0.05), each foot average footprint area and average intensity increased (P <0.05, P <0.01).Conclusion Experimental rat model of vascular dementia in real time gait abnormal behavior and seen in patients with clinical symptoms similar, can provide a reference model for the establishment and judgment .
