Detection of proinflammatory cytokines in serum samples from patients with primary major depres-sive disorder
10.3760/cma.j.issn.0254-5101.2015.01.007
- VernacularTitle:首发重度抑郁症患者血清中促炎物质水平的检测
- Author:
Li ZHANG
;
Jun HE
;
Bin BI
;
Shu ZHANG
;
Qi XU
;
Li ZUO
- Publication Type:Journal Article
- Keywords:
Primary major depressive disorder;
Cytokine;
IL-1α;
IL-6;
IL-18;
TNF-α;
CH50
- From:
Chinese Journal of Microbiology and Immunology
2015;(1):33-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide supportive evidences for the diagnosis of primary major depres-sive disorder (MDD) by analyzing the alterations of proinflammatory cytokines such as IL-1α, IL-6, IL-18, TNF-αas well as the total complement activity (CH50) in serum samples.Methods Hamilton Depression Rating Scale ( HAMD) was used to rate the severity of depression with the patients who were diagnosed as primary MDD.Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of IL-1α, IL-6, IL-18 and TNF-αand the CH50 in serum samples from 49 patients and 40 healthy subjects .Results Pa-tients with MDD showed significantly different levels of IL-6, IL-18, TNF-αand CH50 in serum samples as compared with that in healthy subjects (P<0.05).No significant difference with the level of IL-1αwas ob-served between the patients with MDD and healthy subjects (P>0.05).There were significant gender differ-ences with levels of IL-1αamong the patients with MDD (P<0.05).However, no significant differences with the levels of IL-6, IL-18, TNF-αand CH50 were found between male and female patients (P>0.05). Conclusion The changes of CH50 and certain proinflammatory cytokines such as IL-6, IL-18 and TNF-αmight be involved in the progression of MDD , suggesting the possibility of using them as indicators for the di-agnosis of MDD.
