Correlation of serum osteopontin and leptin levels with femoral head necrosis

VernacularTitle:血清骨桥蛋白及瘦素水平与股骨头坏死的相关性
Author: Zhikun YAN ; Yufeng ZHAO ; Shan YANG ; Huijie LI
Publication Type:Journal Article
From: Chinese Journal of Tissue Engineering Research 2015;19(20):3117-3123
CountryChina
Language:Chinese
Abstract: BACKGROUND:Both osteopontin and leptin are closely linked to bone metabolism, therefore, which may be related to the attack of femoral head necrosis. OBJECTIVE:To study the correlation of serum osteopontin and leptin in the development of femoral head necrosis. METHODS:Thirty-one patients with femoral head necrosis (case group, including 11 cases of ARCO II, 10 of ARCO III, 10 of ARCO IV) and 10 healthy adults (control group) were selected as the research objects. Enzyme-linked immunosorbent assay was used to determine the levels of osteopontin and leptin in serum folowed by statistical analysis. RESULTS AND CONCLUSION:In the case group, the serum levels of osteopontin and leptin were significantly higher than those in the control group (P < 0.05). But the serum levels of osteopontin and leptin showed no correlation between the two groups. These findings indicate that the serum levels of osteopontin and leptin are both elevated in patients with femoral head necrosis, which maybe play a role in the pathogenesis of femoral head necrosis, but there is no obvious correlation.