Relationship between preoperative fibrinogen and prognosis of patients with colon cancer
10.3969/j.issn.1005-6483.2015.01.015
- VernacularTitle:术前纤维蛋白水平与结肠癌预后的关系
- Author:
Yong LIU
;
An XU
- Publication Type:Journal Article
- Keywords:
fibrinogen;
colon cancer;
prognosis
- From:
Journal of Clinical Surgery
2015;(1):40-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic significance of preoperative fibrinogen levels and explore a new prognostic predictor for colon cancer patients. Methods From January 2007 to Decem-ber 2008,the clinical data of colon cancer patients with radical were reviewed retrospectively. Patients were divided into different groups according to BMI,tumor size,stage,differentiation degree,gross type,vascular infiltration,CEA and mGPS score. Differences in preoperative fibrinogen concentration and overall survival were compared between groups. Results A total of 255 patients were enrolled in this study,the mean pre-operative fibrinogen concentration of enrolled patients was(3. 17 ± 0. 88)g/ L. There were significant differ-ences in And preoperative fibrinogen concentration among patients with different tumor size,stage,differen-tiation degree,gross type,vascular infiltration,CEA and mGPS(P < 0. 05). Moreover,result of univariate analysis manifested that the level of preoperative fibrinogen concentration was associated with the overall survival rate. Conclusion Preoperative fibrinogen concentration is associated with the clinicopathologic features of patients with colon cancer,which can serve as a new prognostic marker for prognosis evaluation.
