Stem cell therapy for type 1 diabetes mellitus
10.3969/j.issn.2095-4344.2015.19.024
- VernacularTitle:干细胞治疗1型糖尿病:问题与前景
- Author:
Yu BAI
- Publication Type:Journal Article
- From:Chinese Journal of Tissue Engineering Research
2015;19(19):3096-3101
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Type 1 diabetes melitus is an autoimmune attack characterized by the selective destruction of pancreatic cels. Patients need to rely on external insulin to survive, and there is a lack of specific treatment. OBJECTIVE:To review the source of al kinds of stem cels, differentiation capacity, self-exclusion and existing problems, and to provide the basis for regeneration treatment of type 1 diabetes melitus. METHODS: In order to search relevant article about stem cel therapies for type 1 diabetes melitus from PubMed database (from 2003 to 2015), a computer-based search was performed using the key words of type 1 diabetes melitus, stem cel, stem cel therapy, regeneration treatment, stem-cel differentiation, stem-cel transplantation, immune suppression, insulin secreting cels, islet β-cels, therapeutic effect in English. Finaly, 42 articles were chosen for further analysis. RESULTS AND CONCLUSION:Stem cel therapy for type 1 diabetes melitus has attracted quite a lot of attentions. Restoration of damaged β-cels by exogenous stem cel transplantation is the currently ideal therapeutic options, that is, stem cels cultured under suitable conditions can be induced into islet β-cels that have endocrine function. Through al kinds of research, this paper expounds the source of stem cels, directional differentiation, purification, immune suppression characteristics and existing problems, and it also has a discussion for the occurrence and development of type 1 diabetes melitus so as to select the best scheme of stem cels, which helps to cure the disease.
