Drug therapies for osteoporosis and application of stem cells in bone regeneration medicine: the current and future
10.3969/j.issn.2095-4344.2015.19.026
- VernacularTitle:应用于骨再生医学的干细胞及药物治疗骨质疏松:现状与未来
- Author:
Yuan LIN
;
Shuqing TAO
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2015;19(19):3107-3111
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Besides drug therapy, regenerative therapy is now a matter of global interest in treating osteoporosis. Therefore, it is also important to find better candidate cels. OBJECTIVE:To cognize the status of drug therapies for osteoporosis and stem cels as regenerative therapy. METHODS:A computer-based search of PubMed was performed by the first author to retrieve articles relevant to stem cel therapy for osteoporosis published from January 2000 to December 2014. The keywords were osteoporosis, drug therapy, bone regenerative medicine, stem cel therapy, which appeared in the title, abstract or keywords, and the relevant references were also looked up. Articles published recently or in authoritative journals were preferred, and finaly 39 articles were included in result analysis. RESULTS AND CONCLUSION:Yoshikazu Mikami and co-workers from Japan found two novel bone formation accelerators, SST-VEDI and SSH-BMI, which provides a new direction for related studies on drug therapy. Due to the osteogenesis ability, lack of ethical controversy and less damage, de-differentiated fat cels and pulp stem cels may be promising candidate cels for bone regeneration medicine.
