A meta-analysis of ESRαrs2234693 polymorphism associated with pros-tate cancer risk

VernacularTitle:雌激素受体α基因 rs2234693位点多态性与前列腺癌易感性的 m eta分析
Author: Yingdong MA ; Ani WANG ; Shaoping ZHONG ; Lizi JIN
Publication Type:Journal Article
Keywords: Estrogen receptor α; Genetic polymorphism; Prostatic neoplasms; Meta-analysis
From: Chinese Journal of Pathophysiology 2015;(1):104-108
CountryChina
Language:Chinese
Abstract: AIM:To investigate the pooled association between estrogen receptor α( ESRα) rs2234693 poly-morphism and prostate cancer risk .METHODS:A systematic literature search was performed to identify the related stud-ies (up to April 2014) in several online databases including PubMed , the CNKI and Wanfang online libraries .Odds ratios with 95%confidence intervals were used to calculate the strength of association in the random effect model .RESULTS:A total of 20 studies including 4 623 cases and 9 850 controls were enrolled in the final meta-analysis.The results indicated that ESRαrs2234693 polymorphism was significantly associated with prostate cancer risk (P<0.05) in a dominant genetic model.In the subgroup analysis by ethnicity , there were significant associations between ESRαrs2234693 polymorphism and prostate cancer risk in Caucasians ( P<0.05 ) , but not in Asians and Africans ( both P>0.05 ) .CONCLUSION:This meta-analysis suggests that ESRαrs2234693 polymorphism is significantly associated with prostate cancer risk , espe-cially in Caucasians .