Topiramate for prevention of weight gain with olanzapine:a Meta-analysis
10.3969/j.issn.1671-8348.2015.03.020
- VernacularTitle:托吡酯干预奥氮平所致体质量增高的Meta分析
- Author:
Lili ZHEN
;
Xingfu ZHAO
;
Guanghai PENG
;
Xiaojun ZOU
;
Feng YI
- Publication Type:Journal Article
- Keywords:
topiramate;
olanzapine;
body weight;
Meta-analysis
- From:
Chongqing Medicine
2015;(3):345-348
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess whether topiramate prevents body weight gain in patients with olanzapine .Methods The ran‐domized controlled trials(RCTs) about topiramate for prevention of weight gain with olanzapine from 1998 to 2013 were searched in the Cochrane Library ,Pubmed ,EMbase ,WanFang Data ,CNKI and VIP .Two reviewers independently screened the literatures ,ex‐tracted the data ,and evaluated the methodological quality .Then Meta‐analyses were conducted by using RevMan 5 .1 software .Re‐sults The total of 11 RCTs were included .Among the 549 patients were involved .The results of Meta‐analyses showed that the ef‐ficacy of the topiramate group was superior to that of the control group in lessen body mass with significant difference (MD= -3 .68 ,95% CI:-5 .16- -2 .19 ,Z=4 .86 ,P<0 .01) .Conclusion Topiramate addition therapy is effective in attenuating olanzapine‐induced weight gain .
