The effect of artemisinin on the proliferation of human hepatoma cell line HepG-2
10.3969/j.issn.1671-8348.2015.01.007
- VernacularTitle:青蒿素对肝癌细胞株HepG2细胞增殖的影响
- Author:
Junling HUANG
;
Guangzhi LI
;
Zansong HUANG
;
Yixia YIN
;
Xihan ZHOU
;
Yueqiu QIN
- Publication Type:Journal Article
- Keywords:
artemisinin;
liver neoplasms;
flow cytometry;
cell cycle;
apoptosis
- From:
Chongqing Medicine
2015;(1):21-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of artemisinin on the proliferation of human hepatoma cell line HepG‐2 .Methods The inhibition effect of cell proliferation in human hepatocelluar carcinoma cell line HepG2 of artemisinin was detected by MTT test ,and the cell cycle and apoptosis were detected by Flow cytometry .Results Artemisinin at 80 umol/L could effectively inhibi‐ted the proliferation of HepG‐2 cell in a dose‐and time‐dependent manner;the drugs could block cells at G0/S phase ,and induct the HepG‐2 cell apoptosis .Conclusion Artemisinin could effectively inhibit the proliferation of HepG‐2 cell .
