Abnormally modified tau and hypoxic-ischemic brain damage
10.3969/j.issn.1000-4718.2015.01.034
- VernacularTitle:Tau 的病理性修饰与新生儿缺氧缺血性脑损伤
- Author:
Jie XIAO
;
Fan LI
- Publication Type:Journal Article
- Keywords:
Protein,tau;
Hypoxic-ischemic brain damage;
Dysmyelination;
Glutamate metabolism
- From:
Chinese Journal of Pathophysiology
2015;(1):181-187
- CountryChina
- Language:Chinese
-
Abstract:
Tau is the most abundant microtubule-associated protein in the brain .If tau protein lost the normal function, the toxic effect should be showed and plays an important role in various central nervous system lesions .Hypoxic-ischemic encephalopathy ( HIE) is an important cause of mortality in the neonatal period and it is mainly characterized by neurological deficits such as cognitive limitations .However , the mechanism still needs further study , and the underlying re-lationship between tau protein and HIE lacks direct evidence .Some recent clinical study reported that tau protein expres-sion elevated in the serum of asphyxia children and had a high correlation with behavior deficient .In this review , we focus on 3 key points to provide new insights to understand the tau protein-related pathogenesis of HIE as followed:(1) tau pro-tein and its phosphorylation change during central nervous system development ;(2) comparison of tau protein expression in developing brain and adult brain under some neurological disorders;(3) potential pathological change of tau in HIE related pathological conditions , such as dysmyelination , inflammation response and glutamate metabolism .
