Safety of intravitreal injection of nerve growth factor and its distribution in retina
10.3969/j.issn.1671-8348.2015.03.001
- VernacularTitle:玻璃体腔注射神经生长因子安全性研究及视网膜组织分布
- Author:
Danning LIU
;
Jishan FAN
;
Zhengqin YIN
- Publication Type:Journal Article
- Keywords:
nerve growth factor;
vitrectomy;
retina;
safety
- From:
Chongqing Medicine
2015;(3):289-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe safety of intravitreal injection of mouse nerve growth factor and its distribution in retina in rabbits .Methods The behavioral observation ,slit lamp examination ,fundus examination ,eye B ultrasonic and histopathological ex‐amination were carried out on 1 ,7 and 30 d after intravitreal injection 30 μg/100 μL mNGF to determine the safety in eye .The dis‐tribution and peak time in retina were investigated at 15 ,30 min ,1 ,3 ,6 ,8 ,12 ,24 ,48 h after intravitreal injection 125 I‐NGF 30 μg/100 μL .Results No abnormal changes were found in their cornea ,lens ,vitreous body and retina after mNGF intravitreal injection . And the each layer of retinal cells layout were regular according to the result of morphological observation on 30 days after treat‐ment .The peak concentration of mNGF in retina and the highest in whole eye was (118 .32 ± 18 .74)% ID/g and the peak time was at 3 hour after injection .Conclusion It is safe for intravitreal injection of mNGF and mNGF could gather in retina quickly after in‐travitreal injection .
