Effect of Different Doses of Perindopril on Endothelial Progenitor Cells and Vascular Endothelial Function in Patients With Coronary Artery Disease
10.3969/j.issn.1000-3614.2015.01.007
- VernacularTitle:培哚普利对冠心病患者循环血内皮祖细胞及血管内皮功能的影响
- Author:
Hong TAN
;
Xue WANG
;
Xiaoyan LI
;
Lin XU
;
Li SU
;
Ying HU
;
Yan YANG
;
Yingjian CHEN
;
Guoming ZHANG
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Perindopril;
Endothelial progenitor cells;
Endothelial function
- From:
Chinese Circulation Journal
2015;(1):22-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of different doses of perindopril on peripheral endothelial progenitor cells (EPCs) and vascular endothelial function in patients with coronary artery disease (CAD) .
Methods: A total of 84 CAD patients with coronary angiography confirmed diagnosis were divided into 3 groups: Control group, the patients received routine medication, n=27. Low-dose group, the patients received routine medication with perindopril for 4mg, n=29. High-dose group, the patients received routine medication with perindopril for 8mg, n=28. All patients were treated for 12 weeks. The EPCs level was detected by flow cytometry assay, flow-mediated-dilation (FMD) function in brachial artery was measured by ultrasound and plasma levels of high sensitivity C-reactive protein (hs-CRP), angiotensin II (AngII) were examined in all groups.
Results: ① After12 weeks of treatment, the EPCs level and FMD function had certain improvement, hs-CRP level decreased in various degrees in all 3 groups, P<0.05, and AngII level decreased in both perindopril groups, P<0.05.②After treatment, compared with Control group, both perindopril groups had the increased EPCs level and FMD function, while decreased levels of hs-CRP and AngII, P<0.01.③Compared with Low-dose group, High-dose
group showed increased EPCs level and FMD function, decreased levels of hs-CRP and AgnII, P<0.05.
Conclusion: Perindopril may mobilize peripheral EPCs at certain point, and therefore improve endothelial function, the higher dose of perindopril may have better effect.
