Expression and relationship between forkhead box Q1 and prognosis in NSCLC

VernacularTitle:叉头框蛋白Q1在非小细胞肺癌的表达及其与预后关系
Author: Bin WANG ; Xun ZHANG ; Hua GENG ; Meilin XU ; Haiying ZHOU
Publication Type:Journal Article
Keywords: lung neoplasms; carcinoma,non-small cell lung; prognosis; foxhead box Q1
From: Chongqing Medicine 2015;(1):63-65
CountryChina
Language:Chinese
Abstract: Objective To study the expression of forkhead box Q1(FOXQ1)in non‐small cell lung cancer(NSCLC) ,then investi‐gate clinical pathological characteristics of NSCLC and its prognosis in patients .Methods The expression of FOXQ1 in 84 cases of NSCLC(selected from June 2007 to December 2008 )was detected by immunohistochemistry(SP) .The correlations of the expres‐sion of FOXQ1 with clinic pathological features and survival time of the NSCLC patients were analyzed .Results The positive ex‐pression rate of FOXQ1 was 91 .7% (77/84) ,closely correlated with patients`histological type and TNM stage(P<0 .05) .The Cox multivariate analysis demonstrated that histological type ,TNM stage and FOXQ1expression were independent factors of NSCLC (P<0 .05) .Conclusion The expression of FOXQ1 may be highly expressed in NSCLC and negatively correlated with prognosis .