Effect of serum neuron-specific enolase on prognosis of elderly progressive cerebral infarction
10.3760/cma.j.issn.1008-6706.2015.14.001
- VernacularTitle:血清神经元特异性烯醇化酶对老年人进展性脑梗死预后的影响
- Author:
Yingzhi LU
- Publication Type:Journal Article
- Keywords:
Brain Infarction;
Phosphopyruvate Hydratase;
Prognosis;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(14):2081-2083
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of serum neuron-specific enolase on prognosis of elderly progressive cerebral infarction ( PCI) .Methods 60 senile patients with PCI were selected as the PCI group,at the same time,60 non-cerebral vascular patients were selected as the control group.The patients in both two groups were given basic therapy.Before treatment,serum NSE values,NIHSS score,PCI group infarct area were measured and the prognosis were followed up at 3 months.Results The serum NSE concentration of PCI group was (23.5 ±4.6)ng/mL, which was significantly higher than (4.2 ±1.6)ng/mL of the control group(t=19.41,P<0.01).In PCI group,the serum NSE and NIHSS score in patients with large area infarction were significantly higher than patients with non-massive cerebral infarction(t=4.991,5.985,all P<0.05);The serum NSE and NIHSS scores were significantly higher in patients with disturbance of consciousness than patients with the unconscious barriers(t=6.695,6.055,all P<0.05);The survival was significantly higher compared (t=8.247,6.465,all P<0.05) after March follow-up, death serum NSE and NIHSS score on admission.Conclusion The detection of serum NSE level in patients with senile PCI is conducive to predict the disease,improve the clinical efficacy of the treatment of cerebral infarction.
