Micro-PET Observation of the Effect of Electroacupuncture on Cerebral Hippocampus Glucose Metabolism in SAMP8 Mice with Senile Dementia
10.13460/j.issn.1005-0957.2015.02.0176
- VernacularTitle:运用微型正电子发射扫描技术观察电针对SAMP8老年痴呆小鼠大脑海马区葡萄糖代谢的影响
- Author:
Jing JIANG
;
Kai GAO
;
Yuan ZHOU
;
Xiangbo HAN
;
Zanxun PARK
;
Zhigang LI
- Publication Type:Journal Article
- Keywords:
18 fluorodeoxyglucose;
Hippocampus glucose metabolism;
Electroacupuncture;
SAMP8 mice;
Alzheimer Disease
- From:
Shanghai Journal of Acupuncture and Moxibustion
2015;(2):176-179
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe cerebral hippocampus glucose metabolism using 18F-FDG micro-PET as an imaging technique in a normal group of mice, and model and electroacupuncture groups of SAMP8 mice with senile dementia (rapid aging mice). Method Four 6-month-old SAMR1 mice were picked at random out of the normal group and every four 6-month-old SAMP8 mice, out of the model and electroacupuncture groups respectively. Each of them was anesthetized by inhalation of 2% isoflurane and then given a bolus injection of radioactive tracer 18F-FDG 14.8~16.5 MBq through the tail vein. After one hour of the uptake, a PET scan was performed for 10 min. Hippocampus 18F-FDG uptake rate per gram of brain was calculated in every group of mice and the uptake rates were compared between the groups.Result The 18F-FDG uptake rate per gram of brain tissue was higher in the electroacupuncture group of mice than in the normal and model groups.Conclusion Electroacupuncture can markedly increase cerebral 18F-FDG uptake and the uptake rate per gram of brain tissue in SAMP8 mice. It may play a neuroprotective role through its influence on cerebral glucose metabolism.
