Surveillance of minimal residual disease in acute B-lineage lymphoblastic leukemia
10.3760/cma.j.issn.1009-9921.2013.04.019
- VernacularTitle:急性B淋巴细胞白血病微小残留病的监测
- Author:
Shufen HU
;
Dongmei TAN
- Publication Type:Journal Article
- Keywords:
Leukemia,B-lineage lymphoblastic,acute;
Minimal residual disease;
Flow cytometry
- From:
Journal of Leukemia & Lymphoma
2013;22(4):248-250
- CountryChina
- Language:Chinese
-
Abstract:
Minimal residual disease (MRD) is the cause of relapse in leukemia,and its dynamic monitoring has been a hotspot yet proven to be difficult.MRD in acute B-lineage lymphoblastic leukemia has its own characteristics,normal bone marrow produces a large number of B precursor cells,easily mistaken for leukemia cells,and there were no specific gene alterations that can be conveniently detected.This paper summarizes the antibody combinations in flow cytometry,timing for surveillance and polymerase chain reaction for gene detection,and provide a reference for B lymphocytic leukemia MRD monitoring.
