Effects of Prescription of Nourishing Blood and Stretching of Stoke on TXB2 and 6-Keto-PGF1αof Patients with Acute Ischemic Cerebrovascular Disease
10.3969/j.issn.1005-5304.2015.03.005
- VernacularTitle:自拟中风补血引接方对急性缺血性脑血管病患者血清血栓素B2及6-酮前列腺素F1α的影响
- Author:
Jinhai WANG
;
Hua JIANG
;
Manxia WANG
;
Junfang SHANG
;
Min ZHAO
;
Zhidong LI
;
Yingcun BAO
;
Wude ZHANG
;
Jian GUO
- Publication Type:Journal Article
- Keywords:
acute ischemic cerebrovascular disease;
prescription of nourishing blood and stretching of stoke;
neurologic deficit score;
TXB2;
6-Keto-PGF1α
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(3):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of prescription of nourishing blood and stretching of stoke (PNBSS) on the levels of TXB2 and 6-Keto-PGF1αin serum of patients with acute ischemic cerebrovascular disease (AICD);To discuss its action mechanism in AICD treatment. Methods Ninety patients with AICD were randomly divided into trial group and control group, 45 cases in each group. The control group received western routine treatment, while the trail group received the western routine treatment plus PNBSS, one dose per day, for one week. Rating scale of neurologic deficit was employed to evaluate treatment effectiveness. Venous blood was collected before the treatment and on the 3rd and 7th days of treatment. Levels of TXB2 and 6-Keto-PGF1αin serum were detected respectively. Results The score of neurologic deficit of post-treatment in two groups apparently decreased compared with baseline (P<0.01), and score of neurologic deficit in trial group on 7th day was lower than that of control group (P<0.05). The total effective rate in trial group was 93.3%, which was apparently higher than that of control group (84.4%). The level of TXB2 in serum and ratio of TXB2/6-Keto-PGF1α (T/P) in two groups on 3rd and 7th days remarkably decreased compared with baseline (P<0.01), while the level of 6-Keto-PGF1α in two groups on 3rd and 7th days was higher than that of baseline (P<0.01). Meanwhile, the level of TXB2 and ratio of T/P in two groups on 7th day were apparently lower than that of 3rd day (P<0.01), and the level of 6-Keto-PGF1αon 7th day was higher than that of 3rd day (P<0.01). The level of TXB2 in serum and ratio of T/P on 3rd and 7th days in trial group were apparently lower than that of control group (P<0.01, P<0.05), while the level of 6-Keto-PGF1α on 3rd and 7th days in trial group was apparently higher than that of control group (P<0.01, P<0.05). Conclusion One of the mechanisms of PNBSS for AICD appears to inhibit overavtivity of thrombocyte, and regulate the misadjustment of ratio of T/P.
