SNPs analysis of ABCA4 gene in Han Chinese in Beijing
10.3969/j.issn.1001-3733.2015.01.012
- VernacularTitle:中国北京汉族人群 ABCA4基因的 SNPs 研究
- Author:
Xiaolong ZHANG
;
Hong WANG
- Publication Type:Journal Article
- Keywords:
Single nucleotide polymorphism(SNPs);
ABCA4 gene;
Hap map;
Haploview;
Minor allele frequency (MAF);
Haplotype frequency;
Hardy-Weinberg equilibrium
- From:
Journal of Practical Stomatology
2015;(1):53-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To provide the basis of single nucleotide polymorphism(SNPs)for identification and analysis of ABCA4 gene related etiologic studies in Han Chinese in Beijing(CHB).Methods:SNPs of ABCA4 gene were analyzed for minor allele frequencies (MAFs),haplotype frequencies,linkage disequilibrium patterns,and tag SNPs by Haploview program using the HapMap data.Re-sults:129(37.6%)of 343 SNPs were monotonic.95 tagging SNPs were identified in 214 eligible SNPs with 3 haplotype blocks identi-fied.The frequencies of the top 2 haplotypes among each of the 3 haplotype blocks were between 91.1% and 94.0%.Conclusion:SNPs in ABCA4 gene were analyzed by Haploview program.The analysis provides clues for future studies involving this gene.
