Investigation of Circulating Fractalkine and its Receptor CX3CR1 Levels in Patients With Chronic Congestive Heart Failure
10.3969/j.issn.1000-3614.2014.12.009
- VernacularTitle:慢性充血性心力衰竭患者新型趋化因子循环Fractalkine及其受体CX3CR1水平研究
- Author:
Kang YAO
;
Shuning ZHANG
;
Yan WU
;
Hao LU
;
Zheyong HUANG
;
Juying QIAN
;
Yunzeng ZOU
;
Junbo GE
- Publication Type:Journal Article
- Keywords:
Fractalkine;
Chronic heart failure;
Immune-inlfammatory
- From:
Chinese Circulation Journal
2014;(12):992-995
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the changes of circulating fractalkine and its receptor CX3CR1 level in patients with chronic congestive heart failure (CHF).
Methods: Our work included 2 group, CHF group, n=55 patients and Control group, n=25 healthy subjects. Plasma level of soluble fractalkine (sFKN) was measured by ELISA, CX3CR1 in peripheral blood mononuclear cell was examined by lfow cytometry method. The relationship between sFKN and NT-proBNP was studied.
Results: Compared with Control group, CHF group had increased sFKN level, P=0.004, and the patients with NYHY III, IV were more than NYHY II, and CHF group also had the higher CX3CR1 expression (14.7 ± 8.1), P<0.05. The CX3CR1 level increased accordingly with NYHY classiifcation, as the patients with NYHY II, CX3CR1 was at (25.1 ± 12.4), P=0.03 compare with Control group;with NYHY III, CX3CR1 was at (37.3 ± 11.0) , P=0.04 compared with NYHY II;with NYHY IV, CX3CR1 was at (41.7 ± 11.1), P=0.009 compared with NYHY II. The circulating sFKN level was positively related to pro-BNP level (r=0.364, P<0.01).
Conclusion: The circulating FKN l and its receptor CX3CR1 might be involved in pathogenesis of immune-inlfammatory pathogenesis in CHF patients.
