Correlation Study of Plasma Level NT-ProBNP in Patients With Non-diabetic Acute Myocardial Infarction Combining Stress Hyperglycemia
10.3969/j.issn.1000-3614.2015.01.004
- VernacularTitle:氨基末端B型利钠肽原与非糖尿病急性心肌梗死合并应激性高血糖相关性研究
- Author:
Suiyang TONG
;
Hao XIA
;
Xin WANG
;
Lei LI
;
Hui WANG
;
Dan HUANG
- Publication Type:Journal Article
- Keywords:
N-terminal pro-B-type natriuretic peptide;
Acute myocardial infarction;
Stress hyperglycemia;
Correlation
- From:
Chinese Circulation Journal
2015;(1):9-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the correlation of plasma level N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with non-diabetic acute myocardial infarction (AMI) combining stress hyperglycemia.
Methods: A total of 327 non-diabetic AMI patients treated in our hospital from 2012-02 to 2014-05 were studied. The patients were divided into 2 groups according to fasting blood glucose level:Stress group, the patients with blood glucose≥7.0 mmol/L, n=182 and Non-stress group, the patients with blood glucose<7.0 mmol/L, n=145. The basic clinical condition, laboratory tests within 24 hours of onsets, echocardiography and 24 h dynamic electrocardiogram were examined;the incidence of major adverse cardiovascular events (MACE) including arrhythmia, heart failure, cardiac shock and sudden cardiac death in 2 weeks of onsets were analyzed and compared between 2 groups.
Results: The patients’ age, gender, history of hypertension, smoking, drinking, and blood levels of TC, TG, HDL-C, LDL-C were similar between 2 groups, P>0.05. Plasma levels of NT-proBNP, CK-MB, MYO, ultra-TnI, ALT, AST and blood glucose level were signiifcantly different between 2 groups P<0.01. NT-proBNP level was positively related to
ultra-TnI (r2=0.811, r=0.901, P<0.01). Stress group presented obviously higher incidence of MACE (P<0.05), lower LVEF (P<0.01), and signiifcantly increased left ventricular end diastolic diameter, left ventricular end systolic diameter (P<0.01) than those in Non-stress group.
Conclusion: Plasma levels of NT-proBNP may judge the severity and evaluate recent prognosis in patients with non-diabetic AMI combining stress hyperglycemia, it could be used as a risk indicator for relevant patients in clinical practice.
