Efficacy and Safety of Low Dose Erythropoietin for Treating the Patients With Acute Myocardial Infarction After Percutaneous Coronary Intervention
10.3969/j.issn.1000-3614.2015.01.006
- VernacularTitle:低剂量促红细胞生成素用于急性心肌梗死患者经皮冠状动脉介入治疗术后的疗效和安全性
- Author:
Yanming LI
;
Han ZHANG
;
Ruili HE
;
Guanchang CHENG
- Publication Type:Journal Article
- Keywords:
Erythropoietin;
Acute myocardial infarction;
Percutaneous coronary intervention;
Low dose;
Clinical effect;
safety
- From:
Chinese Circulation Journal
2015;(1):17-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the efifcacy and safety of low dose erythropoietin (EPO) for treating the patients with acute myocardial infarction (AMI) after percutaneous coronary intervention procedure.
Methods: A total of 80 patients of acute STEMI with successful PCI were randomized into 2 groups. EPO group, the patients received intravenous EPO 6000 IU in 100 ml of normal saline at immediately and 2, 4 days after PCI. Control group, the patients received 100 ml of normal saline at the same time points. n=40 in each group. The patients were followed-up for 6 months for routine blood test, left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume index (LVEDVI), left ventricular end-systolic volume index (LVESVI), the size of infarction, and plasma levels of BNP, hemoglobin. The major adverse cardiovascular events (MACE) and EPO related side effects were compared between 2 groups.
Results: The baseline condition was similar between 2 groups. With 6 months of treatment, EPO group showed obviously improved LVEF at 4 days after PCI, and decreased size of infarction, all P<0.05, while those indexes were similar in Control group, all P>0.05. In EPO group, with 6 months of treatment, LVESVI decreased from (49.76±32.65 ) ml/m2 to (34.78±19.98)
ml/m2, LVEDVI decreased from (92.23±27.65) ml/m2 to (84.52±25.76) ml/m2, all P>0.05, and in Control group, LVEDVI increased from (91.78±41.67) ml/m2 to (93.71±31.25) ml/m2, P>0.05. The incidence of MACE and EPO related side effects were similar between 2 groups, P>0.05.
Conclusion: Low dose EPO administration was effective and safe for treating AMI patients after PCI procedure.
