Relationship Between Plasma Level of NT-proBNP and Ventricular Diastolic Dysfunction in Elder Hypertensive Patients Without Target Organ Damage
10.3969/j.issn.1000-3614.2015.01.011
- VernacularTitle:老年无靶器官损害的高血压患者血浆N末端B型利钠肽原水平与心室舒张功能减退的相关性分析
- Author:
Yuanjun WANG
;
Faman YANG
;
Ji LIU
;
Rong LI
;
Peili ZHANG
- Publication Type:Journal Article
- Keywords:
N-terminal B-type natriuretic peptide;
Hypertension;
Diastolic dysfunction;
Pearson correlation
- From:
Chinese Circulation Journal
2015;(1):38-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the relationship between plasma level of N-terminal B-type natriuretic peptide (NT-proBNP) and ventricular diastolic dysfunction in elder hypertensive patients without target organ damage.
Methods: A total of 66 relevant patients treated in our hospital from 2012-03 to 2014-03 were studied. According to the standard of ventricular diastolic dysfunction, the patients were divided into 2 groups: Study group, n=27 patients with diastolic dysfunction and Control group, n=39 patients without diastolic dysfunction. The patients in Study group were further divided into 3 sub-groups based on Doppler classification of diastolic dysfunction:Grade 1, the patients with E/A<1.0, DT≥240 ms, IVRT>90 ms, n=8. Grade 2, the patients with E/A>1.5, DT (150-220) ms, IVRT<90 ms, n=13. Grade 3-4, the patients with E/A>1.5, DT≤150 ms, IVRT<70 ms, n=6. Plasma levels of NT-proBNP and Doppler ultrasound findings were compared to study the relationship between
NT-proBNP and ventricular diastolic dysfunction.
Results: Plasma level of NT-proBNP was higher in Study group than that in Control group. NT-proBNP level in Grade 3-4 sub-group was obviously higher than those in Grade 1 and Grade 2 sub-groups, NT-proBNP level in Grade 2 sub-group was higher than that in Grade 1 sub-group. Pearson correlation analysis indicated that NT-proBNP level was positively related to systolic blood pressure, diastolic function and E/E’ (r=0.211, P=0.037, r=0.442, P=0.004 and r=0.556, P=0.000), while negatively related to E’/A’ (r=-0.372, P=0.000).
Conclusion: The increased plasma level of NT-proBNP are highly support for ventricular diastolic dysfunction in elder hypertensive patients without target organ damage, NT-proBNP level is related to ventricular diastolic function.
