Immunity of Human Cytomegalovirus in Patients of Coronary Artery Disease With its Clinical Efficacy
10.3969/j.issn.1000-3614.2014.12.005
- VernacularTitle:人巨细胞病毒在冠心病患者中的免疫调节作用及其临床意义
- Author:
Guanjia NING
;
Moshui CHEN
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Human cytomegalovirus;
Treg cell
- From:
Chinese Circulation Journal
2014;(12):976-978
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To detect the infectious condition of human cytomegalovirus (HCMV) in coronary artery disease (CAD) patients and to explore the effect of HCMV infection on Treg cells in CAD patieuts.
Methods: A total of 86 CAD patients treated in our hospital from 2012-04 to 2014-05 were studied. The patients were divided into 2 groups:Angina Pectoris (AP) group, n=46 and Acute myocardial infarction (AMI) group, n=40. In addition, there was a Control group with 80 healthy subjects. The Treg cell amount was detected by lfow cytometry analysis, the expression levels of HCMV and IL-10, IL-6, TNF-αwere examined by ELISA.
Results: The positive rate of HCMV infection was higher in CAD group than that in Control group as 72.1%vs 27.5%, P<0.05. The ratio of Treg cell and the levels of IL-10, IL-6, TNF-αexpression in CAD group were (3.32 ± 0.73)%and (16.54 ± 3.84)μg/ml, (28.91 ± 4.38)μg/ml, (36.34 ± 6.05)μg/ml, while in Control group were (6.38 ± 1.42)%and (27.84 ± 4.23)μg/ml, (9.12 ± 2.12)μg/ml, (16.42 ± 2.57)μg/ml respectively, all P<0.01. The positive rate of HCMV infection was higher in AMI group than that in AP group as 85.0%vs 60.9%, P<0.05. The ratio of Treg cell and the levels of IL-10, IL-6, TNF-αexpression in AP group were (4.24 ± 1.03)%and (21.43 ± 4.16)μg/ml, (20.55 ± 3.43)μg/ml, (31.12 ± 5.83)μg/ml, while in AMI group were (2.06 ± 0.52)%and (10.91 ± 2.23)μg/ml, (36.58 ± 5.72)μg/ml, (44.49 ± 7.24)μg/ml respectively, all P<0.01.
Conclusion: CAD patients had the higher positive rate of HCMV infection, which may inhibit Treg cell production and then, involved in CAD occurrence and development.
