Relationship Between High-sensitivity C-reactive Protein and P Wave Dispersion in Patients With Lone Paroxysmal Atrial Fibrillation
10.3969/j.issn.1000-3614.2014.12.007
- VernacularTitle:孤立性阵发性心房颤动患者高敏C反应蛋白与P波离散度的关系
- Author:
Lihui ZHENG
;
Yan YAO
;
Lingmin WU
;
Kuijun ZHANG
;
Shu ZHANG
- Publication Type:Journal Article
- Keywords:
Atrial ifbrillation;
Inlfammation;
P wave dispersion;
High sensitivity C-reactive protein
- From:
Chinese Circulation Journal
2014;(12):983-986
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the relationship between high-sensitivity C-reactive protein (hs-CRP) and P wave dispersion (Pd) in patients with lone atrial ifbrillation (AF), and to explore the effect of inlfammation on atrial electrophysiological remodeling.
Methods: Our research included 2 groups. AF group, containing 71 consecutive paroxysmal lone AF patients, and Control group, containing 71 paroxysmal supra ventricular tachycardia patients with the matched age and gender. The clinical characteristics, electrocardiographic Pd assessment and plasma hs-CRP levels were compared between 2 groups. The relationship between hs-CRP and Pd was studied by linear and multi linear regression analysis.
Results: Compared with Control group, AF group showed increased left atrial diameter, Pd and hs-CRP, all P<0.05. multilinear regression analysis indicated that hs-CRP was positively related to Pd in both groups, P<0.01. Multiple logistic regression analysis revealed that hs-CRP was an independent risk factor for AF occurrence (HR=15.430, 95%CI 6.031-39.476, P<0.001), with adjusted Pd, multiple logistic regression analysis presented that both Pd and hs-CRP were the independent risk factors for AF occurrence, both P<0.001, while the HR for hs-CRP predicting AF occurrence was attenuated from 15.430 to 6.246.
Conclusion: Plasma hs-CRP level and electrocardiographic Pd were the important risk factors for paroxysmal lone AF, the interaction between hs-CRP and AF occurrence could be mediated by Pd, suggesting that inlfammation might be involved in atrial electrophysiological remodeling.
