Research progress on the role of platelet in mediating tumor metastasis by hematogenous spread and its mechanisms
10.3969/j.issn.1001-1978.2015.02.005
- VernacularTitle:血小板介导肿瘤血行转移的作用及其机制研究进展
- Author:
Yuzhu CAO
;
Zhaoguo LIU
;
Yunlong SHAN
;
Lihua SUN
;
Yuping LIU
;
Zhonghong WEI
;
Pinting ZHU
;
Hongyan WU
;
Aiyun WANG
;
Wenxing CHEN
;
Shizhong ZHENG
;
Yin LU
- Publication Type:Journal Article
- Keywords:
platelet;
tumor embolus;
tumor hematogenous spread;
molecular mechanisms;
therapy strategies;
clinical ap-plication
- From:
Chinese Pharmacological Bulletin
2015;(2):166-169
- CountryChina
- Language:Chinese
-
Abstract:
Tumor metastasis is one of the most important biologi-cal characteristics of malignant tumor, and it is also the main factors that cause treatment failure and poor prognosis. Clinical studies have shown that the number of platelets in patients with malignant tumor increased more significantly than that in benign tumor patients and healthy people, which indicate that platelet might be involved in the development process of tumor. Further study found that in the process of cancer spreading to blood, platelet could interact with tumor cells to form tumor emboli, helped tumor cells escape from immune surveillance, thus pro-moted the tumor metastasis. In recent years, related mechanisms on platelets in promoting tumor metastasis were revealed gradual-ly, and several targeted therapies based on platelets were also carried out. This paper reviews the role of platelet in mediating tumor metastasis by hematogenous spread and its mechanisms and discusses the therapy strategies that target platelet, which may provide references for follow-up research and clinical treat-ment.
