Clinical significance of cystatin C in coronary artery disease risk evaluation
10.3760/cma.j.issn.1008-6706.2015.14.017
- VernacularTitle:血清胱抑素C检测对冠心病风险的评估价值
- Author:
Bao WANG
- Publication Type:Journal Article
- Keywords:
Cystatin C;
Coronary Artery Disease;
Acute Coronary Syndrome;
ROC Curve
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(14):2135-2137
- CountryChina
- Language:Chinese
-
Abstract:
Objective .To evaluate the role of cystatin c in the risk judgement of coronary artery disease. Methods 77 patients with coronary artery disease were involved in the study.They were divided into two groups:Group 1 were patients with angiographically diagnosed coronary artery disease ( CAD) with their first acute coronary syndrome ( n=55);Group 2 were patients who had clinically diagnosed coronary disease but were negative on angiog-raphy ( n=22) .Serum Cys C levels in the two groups and the correlation to CAD were analyzed.Results Serum Cys C levels in patients of Group 1 were higher than that of Group 2 [(1.23 ±1.07)mg/L vs.(0.71 ±0.32)mg/L,P=0.002],but no significant difference was found between the two groups in crea levels [(123.76 ±80.44)μmmol/L vs.(117.63 ±65.43)μmmol/L,P=0.230].A ROC analysis revealed that there was a significantly higher risk of ACS above a cystatin c level of 0.875mg/mL (sensitivity:84.3%,specificity:38.8%).A similar analysis carried out for eGFR did not find any significant cut-off points above which risk of ACS was higher.Conclusion The data showed that a high level of cystatin c level is a risk factor for ACS.This could play an important role in the early diag-nosis and prevention of adverse cardiovascular events.
