Clinical effect of active immunotherapy combined with endometrial local injury treatment in women with recurrent spontaneous abortion
10.3760/cma.j.issn.1008-6706.2015.14.038
- VernacularTitle:主动免疫治疗联合子宫内膜轻创术治疗复发性流产疗效分析
- Author:
Wenyuan LI
;
Zhiyong WANG
;
Yu WANG
;
Chenjing ZHANG
;
Li MENG
;
Lina QIN
;
Xiaojie PEI
- Publication Type:Journal Article
- Keywords:
Abortion,Habitual;
Antibodies,Blocking;
Imunotherapy,Active;
Endometrium
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(14):2198-2200
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of active immunotherapy combined with endometrial local injury in women with recurrent spontaneous abortion( RSA) caused by negative-blocking antibodies.Methods 112 patients diagnosed RSA with negative -blocking antibodies were randomly divided into the treatment group (62 patients) and control group (50 patients).The patients in treatment group were treated by active immunotherapy combined with endometrial local injury.The patients in the control group were treated by active immunotherapy.The pregnancy outcomes were observed.Results The rate of pregnancy was 93.54%in treatment group,and 80.00%in the control group.The success pregnancy rate in the treatment group was significant higher than that in the control group (χ2 =4.65,P<0.05).The rate of abortion was 3.44% in the treatment group and 12.50% in the control group.It was significant lower than the control group(χ2 =4.90,P<0.05).After active immunotherapy,the pregnan-cy rate was 90.58%in positive-blocking antibodies group and 77.77%in negative-blocking antibodies group.The success pregnancy rate in positive-blocking antibodies group was significant higher than that in negative-blocking antibodies group (χ2 =4.27,P<0.05).The abortion rate in positive-blocking antibodies group was 2.60% and 19.05%in negative-blocking antibodies group.It was significant lower than that in negative-blocking antibodies group (χ2 =6.14,P<0.05).Conclusion It can significantly improve pregnant outcome and reduce the abortion rate with active immunotherapy combined with endometrial local injury in women with recurrent spontaneous abortion ( RSA) caused by negative-blocking antibodies.
