Hepatitis B virus replication mechanisms and drug targets of chronic hepatitis B
10.3969/j.issn.1001-1978.2015.02.002
- VernacularTitle:HBV病毒复制机制及慢性乙型肝炎药物靶点
- Author:
Xiaolin HE
;
Jianwei HUANG
;
Ruian XU
;
Xiuling CUI
- Publication Type:Journal Article
- Keywords:
hepatitis B virus;
viral replication;
drug targets;
as-sembly;
NTPC;
core protein
- From:
Chinese Pharmacological Bulletin
2015;(2):152-156
- CountryChina
- Language:Chinese
-
Abstract:
Hepatits B virus( HBV) infection is a global epidemic which seriously harms the public health. In spite of the great progress in hepatits B prevention and treatment, there is few ef-fective medicine. Research findings show that liver damage and degree of liver failure are sophisticatedly related to the interaction between HBV and the immune response of host. All these make it important to know the replication mechanism and the contrac-tion process, in order to lay a preliminary solid foundation for studying HBV drug targets and making a new ant-virus strategy. This article aims to summarize HBV viral replication process, while focusing on the latest research findings about drug targets, to find a new kind of anti-HBV drugs, and to explore the under-lying mechanism of effective drugs.
