Effects of taurine on platelet aggregation induced by benzo pyrene in vitro activation function
- VernacularTitle:牛磺酸对苯并芘体外诱导血小板聚集活化功能的影响
- Author:
Guoxiang YANG
;
Yuanhong XU
- Publication Type:Journal Article
- Keywords:
benzo pyrene;
taurine;
platelet function;
flow cytometry
- From:
Acta Universitatis Medicinalis Anhui
2015;(1):116-118
- CountryChina
- Language:Chinese
-
Abstract:
The peripheral renous blood which were taken from healthy volunteers and platelet was isolated. Platelet samples were randomly divided into six groups. The effects of different concentration of taurine( Tau) on benzo py-rene( BAP) induced platelet aggregation in vitro activation function were investigated by detecting the maximum platelet aggregation rate, the positive expression rates of platelet membrane surface CD62P and PAC-1. The results showed that platelet maximum aggregation rate had significant differences between each concentration of BAP-Tau groups and solvent control group in adenosine diphosphate(ADP) and collagen induced (P<0. 01). The positive expression rates of platelet membrane surface CD62 P and PAC-1 in BAP-Tau high concentration group had signifi-cant differences compared with solvent control group ( P<0. 01 ) . Different concentration of Tau could antagonize platelet function damage induced by BAP with a concentration gradient change.
