Effect of Tanggankang on the Expression of CREB in Diabetic-fatty Liver Rats

VernacularTitle:糖肝康对糖尿病脂肪肝大鼠肝组织cAMP反应元件结合蛋白表达的影响
Author: Qiuhai QIAN ; Weibin QIAN ; Xinrui CAI ; Jing ZHANG ; Wei PENG
Publication Type:Journal Article
Keywords: Tanggankang; fatty liver; diabetes mellitus; CREB; rats
From: Chinese Journal of Information on Traditional Chinese Medicine 2015;(2):71-73
CountryChina
Language:Chinese
Abstract: Objective To observe the effect of Tanggankang on the expression of CREB in diabetic-fatty liver rats;To investigate the mechanism of Tanggankang. Methods STZ and feeding high fat forage induced diabetic rats were randomly divided into model group, Huganning group, Tanggankang high dose group, Tanggankang medium dose group, Tanggankang low dose group, 10 rats in each group, with 10 normal rats as control. After 12 weeks of drug intervention, rats were killed, the livers were removed, and the expression of CREB was detected by Western blot. Results Compared with normal group, the level of CREB of model group was significantly decreased (P<0.01). Compared with model group, Tanggankang low, medium and high dose group significantly decreased the level of CREB (P<0.01). Conclusion Tanggankang may play an active role in glucose and lipid metabolism by affecting the expression of CREB.