Optimization of Inclusion Compound for Osthol with Hydroxypropyl-β-Cyclodextrin by Orthogonal and Rotational Combination Design
10.3969/j.issn.1005-5304.2015.02.023
- VernacularTitle:二次正交旋转组合设计法优化蛇床子素羟丙基-β-环糊精包合工艺
- Author:
Rui WANG
;
Lili YAN
;
Guoliang XIE
;
Jing YANG
;
Yannan LIU
;
Yanhong WANG
;
Weinan LI
;
Qingxia GUAN
;
Yongji LI
- Publication Type:Journal Article
- Keywords:
osthol;
preparation process;
hydroxypropyl-β-cyclodextrin;
orthogonal and rotational combination design
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(2):83-85
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the process of hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion techniques for osthol. Methods The inclusion complex of osthol and HP-β-CD was prepared by unsaturated water solution and freeze-drying technique. Inclusion techniques were selected by screening on quadratic orthogonal rotation combination design method, and the entrapment efficiency was identified by HPLC. Results The optimal technical conditions were as follows:the ratio of HP-β-CD and drug was 4.5∶1;temperature for electric mixer was 35 ℃;the stirring time for thermostatic waterbath was 210 min. Conclusion This method is reasonable and it may have a prosperous future of development and application.
