Effects of rapamycin induced cellular autophagy in aging-related diseases
10.3969/j.issn.1001-1978.2015.01.003
- VernacularTitle:雷帕霉素诱导细胞自噬在衰老相关疾病中的作用
- Author:
Boyan WU
;
Xinguang LIU
;
Weichun CHEN
- Publication Type:Journal Article
- Keywords:
rapamycin;
TOR;
autophagy;
HGPS;
progerin;
neurodegenerative diseases
- From:
Chinese Pharmacological Bulletin
2015;(1):11-14
- CountryChina
- Language:Chinese
-
Abstract:
Mammalian target of rapamycin( mTOR) is a key reg-ulator of aging and aging-related diseases. Rapamycin ( RAPA) induces and promotes the process of cell autophagy through in-hibiting mTOR pathway. Autophagy exerts a crucial role in main-taining the cellular meostasis, which provides essential materials for cell reconstruction, regeneration and repair via degradating the redundant, damaged, or senescent proteins and organelles. Hutchinson Gilford progeria syndrome ( HGPS ) patients are al-ways accompanied with abnormally accumulated progerin in cells. Similar to HGPS, abnormal protein accumulation is the common pathological feature of neurodegenerative diseases, in-cluding Huntington′s disease, Parkinson′s disease, Alzheimer′s disease and so on. Degradation of these abnormal proteins pre-dominantly depends on cell autophagy. Thus, rapamycin is a po-tential anti-aging drug for HGPS and aging-related diseases thera-py. This view focuses on the effects of rapamycin on cell autoph-agy and clinical application in HGPS and neurodegenerative dis-eases.
