Progress on brain-derived neurotrophic factor participating in pain-depression comorbidity
10.3969/j.issn.1001-1978.2015.01.007
- VernacularTitle:脑源性生长因子参与疼痛-抑郁共病的研究进展
- Author:
Di LIU
;
Qianqian TANG
;
Junli CAO
- Publication Type:Journal Article
- Keywords:
pain;
depression;
BDNF;
hippocampus;
prefrontal cortex;
amygdale;
ventral tegmental area;
nucleus accumbens
- From:
Chinese Pharmacological Bulletin
2015;(1):26-30
- CountryChina
- Language:Chinese
-
Abstract:
The comorbidity of pain and depression is common. Both disorders might share common neuroanatomical and molecu-lar mechanisms. Recent studies have found that the brain-de-rived neurotrophic factor( BDNF) ,which plays an important role in the process of pain-depression comorbidity, has gradually be-come a hot topic and target of treatment. The article mainly sum-marizes the mechanism underlying comorbid pain and depres-sion,as well as the significance of blood BDNF in diagnosis and treatment of pain and depression.
