Anti-inflammatory and Analgesic Activity of Rupixiao Granules
- VernacularTitle:乳癖消颗粒抗炎镇痛作用实验研究
- Author:
Lu ZHONG
;
Hongyu JI
;
Shuyuan WANG
;
Hongmei LIU
;
Yidan ZHANG
;
Linhua WU
- Publication Type:Journal Article
- Keywords:
Rupixiao granules;
Anti-inflammation;
Analgesia
- From:
China Pharmacist
2015;(1):149-151
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the anti-inflammatory and analgesic effects of Rupixiao granules. Methods:Activity of Rupixi-ao granules against xylene-induced ear edema in mice was measured to evaluate the anti-inflammatory effect, while the analgesic effect was evaluated by acetic acid induced writhing test and hot plate test in mice. Results:Compared with the control group, Rupixiao gran-ules groups (1. 0, 2. 0 and 4. 0 g·kg·d-1) could significantly inhibit ear swelling in mice(P<0. 05 or 0. 001), and reduce the acetic acid induced writhing times(P<0. 01 or 0. 001). Rupixiao granules at medium and high dose could significantly increase the pain thresh-old of mice in the hot plate test. Conclusion:Rupixiao granules exhibit significant anti-inflammatory and analgesic activities.
