Non-alcoholic Fatty Liver Disease and Chronic Kidney Disease in Koreans Aged 50 Years or Older.
10.4082/kjfm.2013.34.3.199
- Author:
Ah Leum AHN
1
;
Jae Kyung CHOI
;
Mi Na KIM
;
Seun Ah KIM
;
Eun Jung OH
;
Hyuk Jung KWEON
;
Dong Yung CHO
Author Information
1. Department of Family Medicine, Konkuk University School of Medicine, Seoul, Korea. cjk@kuh.ac.kr
- Publication Type:Original Article
- Keywords:
Non-alcoholic Fatty Liver Disease;
Chronic Renal Insufficiency;
Ultrasonography;
Glomerular Filtration Rate;
Proteinuria
- MeSH:
Academic Medical Centers;
Aged;
Alanine;
Aspartate Aminotransferases;
Cardiovascular Diseases;
Cholesterol;
Cross-Sectional Studies;
Diabetes Mellitus;
Fatty Liver;
gamma-Glutamyltransferase;
Glomerular Filtration Rate;
Humans;
Hypertension;
Hypertriglyceridemia;
Lipoproteins;
Liver;
Logistic Models;
Obesity, Abdominal;
Proteinuria;
Renal Insufficiency, Chronic;
Risk Factors;
Smoke;
Smoking;
Transaminases
- From:Korean Journal of Family Medicine
2013;34(3):199-205
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share common pathogenic mechanisms and many risk factors, and both are linked to an increased risk of cardiovascular diseases. The aim of this study was to assess the association between NAFLD and CKD according to the presence of hypertension and diabetes mellitus in Koreans aged 50 years or older. METHODS: A cross-sectional study of 1,706 subjects who received their routine health examination was conducted between May 2008 and April 2010 at Konkuk University medical center. Biochemical tests for liver and abdominal ultrasonography were performed. CKD was defined as either proteinuria or glomerular filtration rate < or =60 mL/min per 1.73 m2. RESULTS: Among the 1,706 subjects, There were 545 (31.9%) with non-alcoholic fatty liver disease and 424 (24.9%) with chronic kidney disease. In univariate logistic regression analysis, NAFLD was significantly associated with CKD (odds ratio [OR], 1.69; 95% confidence interval [CI], 1.34 to 2.12). In multivariate logistic regression analysis adjusted for age, sex, current smoking, abdominal obesity, aspartate aminotransferases, alanine aminotransferases, gamma-glutamyltransferase, hypertension, diabetes mellitus, hypertriglyceridemia, and low high-density lipoprotein cholesterol, NAFLD was associated with CKD (adjusted OR, 1.68; 95% CI, 1.27 to 2.24). This relationship remained significant after classification according to the presence of hypertension or diabetes mellitus. CONCLUSION: NAFLD diagnosed by ultrasonography was significantly associated with CKD in Koreans aged 50 years or older.
