Expression and significance of NF-κB and MCP-1 in endometrial carcinoma

VernacularTitle:子宫内膜癌中NF-κB、MCP-1蛋白的表达及意义
Author: Caixia LI ; Ling JIANG ; Wei DENG ; Jiangsheng HUANG
Publication Type:Journal Article
Keywords: endometrial neoplasms; NF-κB; MCP-1; immunohistochemistry
From: Chongqing Medicine 2015;(1):36-39
CountryChina
Language:Chinese
Abstract: Objective To detect the expression of NF‐κB ,MCP‐1 in the endometrial carcinoma and their significance .Methods The expression of NF‐κB ,MCP‐1 in 52 cases of patients with endometrial carcinoma selected from January 2003 to December 2013 , and in 16 cases of endometrial atypical hyperplasia and 19 cases of proliferative endometrial were detected by immunohistochemistry assay .The relationship and correlation between clinical pathological characteristics was analyzed .Results The expressions of NF‐κB ,MCP‐1 proteins were significantly higher in the endometrial carcinoma than those of the endometrial atypical hyperplasia and proliferative endometrial (P<0 .05) .The expressions of NF‐κB and MCP‐1 were related with histological grade and myometrial in‐vasion (P<0 .05) ,but independent of clinical stage and lymph node metastasis (P>0 .05) .The expressions of these two proteins were positively correlated(r=0 .895 ,P<0 .05) .Conclusion NF‐κB ,MCP‐1 may participate in the progress of endometrial carcino‐ma .