The effect of rosuvastatin on the vascular endothelial function,inflammatory factors and prognosis in patients with acute coronary syndrome after percutaneous coronary intervention
10.3969/j.issn.1671-8348.2015.01.018
- VernacularTitle:瑞舒伐他汀对急性冠状动脉综合征患者介入后血管内皮功能、血清炎症因子和预后的影响
- Author:
Xiaoyan DUAN
;
Xiaolan REN
;
Jianzhong YU
- Publication Type:Journal Article
- Keywords:
acute coronary syndrome;
endothelium,vascular;
rosuvastatin;
percutaneous coronary intervention;
inflammatory fac-tors;
prognosis
- From:
Chongqing Medicine
2015;(1):52-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of rosuvastatin(RSVT) on the vascular endothelial function(VEF) ,inflammatory fac‐tors(IF) and prognosis in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention(PCI) .Methods Eighty cases of ACS patients with PCI in our hospital selected from July 2010 to July 2013 were randomly divided into observed group and control group ,40 cases in each group .The observation group were given interference treatment with RSVT while the control group received conventional treatment .The VEF ,IF and prognosis were compared between groups .Results The VWF at 4 weeks after PCI in observation group was lower than that in control group [(92 .6 ± 12 .3)% vs .(105 .4 ± 13 .6)% ,P<0 .05];The ET‐1 at 4 weeks after PCI in observation group was lower than that in control group[(55 .6 ± 5 .6)ng/L vs .(67 .8 ± 7 .4)ng/L ,P<0 .05] .The NO at 4 weeks after PCI in observation group was higher than that of control group[(78 .6 ± 9 .4)μmol/L vs .(63 .2 ± 9 .5)μmol/L ,P<0 .05] .The CRP at 4 weeks after PCI in observation group was lower than that in control group[(5 .4 ± 2 .2) mg/L vs .(10 .5 ± 4 .1)mg/L ,P<0 .05] .The incidence of CVE was 5 .00% (2/40) ,restenosis rate was 2 .50% (1/40) in observa‐tion group ,which was significantly lower than those of the control group [30 .00% (12/40) ,10 .00% (4/40)] ,the differences were statistically significant(P<0 .05) .Conclusion RSVT could effectively improve the VEF and reduce inflammation ,CVE and rest‐enosis rate in patients with ACS after PCI .
