Analysis of clinicopathologic features and prognostic factors of 30 patients with extramamma-ry Paget’ s disease
10.13315/j.cnki.cjcep.2014.11.003
- VernacularTitle:30例乳腺外Paget病的临床病理及预后分析
- Author:
Ying LIU
;
Xinhua ZHANG
;
Bo YU
;
Qunli SHI
- Publication Type:Journal Article
- Keywords:
Paget’ s disease;
extramammary;
pathology;
prognosis;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(11):1211-1214
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To evaluate the clinical and pathological features of extramammary Paget’ s disease ( EMPD) and to investigate the related prognostic factors. Methods The clinical and pathological data of 30 patients with EMPD were reviewed retrospectively. The HE slides in the file were rechecked. Immunohistochemical stains were performed on archival paraffin-embedded sections with En-Vision method in 20 cases. Follow-up data were recorded. The relationship between the clinicopathological parameters and prognosis was statistically analyzed. Results Among the 30 patients, there were 26 males and 4 females, aged from 53 to 88 years with median age 70. Macroscopically, typical presentations of EMPD were eczematoid lesions. Microscopically, Paget’s cells were distributed sin-gly or in groups ( as glandular or nests patterns) within the epidermis. Immunohistochemical stains showed that Paget’ s cells were pos-itive for CK7, and negative for CK5/6 and p63. Follow-up data were available in 23 cases, 8 cases recurred resection, among them, 6 patients had positive resected margin and 4 died. The recurrent rate and mortality between the groups of dermal invasion and no der-mal invasion (P<0. 01 and P<0. 05), the groups of lymphatic metastasis and no lymphatic metastasis (P<0. 01), and the groups of positive and negative resected margin (P<0. 01 and P<0. 05) were statistically different. There were no statistically different with age and extent of lesion (P>0. 05). Conclusions CK7 is a sensitive and specific marker of Paget’s cells. Dermal invasion, lymphatic metastasis and positive resected margin are poor prognostic factors in EMPD.
