Value of ERG in the diagnosis of vascular tumor
10.13315/j.cnki.cjcep.2014.11.015
- VernacularTitle:血管源性肿瘤中ERG蛋白的诊断价值
- Author:
Hongying ZHANG
;
Wenbin HUANG
- Publication Type:Journal Article
- Keywords:
hemangioma;
angiosarcoma;
ERG;
CD31;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(11):1263-1265
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the expression of ERG in various vascular tumors, and to explore the value of ERG in the diagnosis of vascular tumor. Methods Immunohistochemical EnVision method was used to detect the expression of ERG and CD31 in 30 cases of vascular tumor and 20 cases of non-vascular tumor. Results All vascular tumors diffusely expressed ERG and CD31. Expression of ERG was unrelated to tumor histologic type and benign or malignant. Expression of ERG was consistent with CD31. Of 20 non-vascular tumors, all except for one cases of epithelial sarcoma did not express ERG. The sensitivity and specificity of ERG in the diagnosis of vascular tumor were 100% and 96. 7%. Conclusion ERG is a high sensitive and specific marker for vascular-derived tumor. The combinated detection of ERG and CD31 may useful for the diagnosis and differential diagnosis of vascular tumor.
