Correlation of primary hyperuricemia and apolipoprotein E gene polymorphism
10.7644/j.issn.1674-9960.2014.12.004
- VernacularTitle:原发性高尿酸血症与载脂蛋白E基因多态性的关联性研究
- Author:
Jiancai DU
;
Lina ZHOU
;
Bo LU
;
Zhongqin GUO
- Publication Type:Journal Article
- Keywords:
primary hyperuricemia;
apolipoprotein E;
gene polymorphism
- From:
Military Medical Sciences
2014;(12):936-939
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation of primary hyperuricemia and apolipoprotein E gene polymorphism between Hui and Han nationalities in Ningxia , and provide data for disease control and prevention .Methods Blood sam-ples,obtained from 900 cases at some medical institutions for case-control study, were detected for gene polymorphism of apolipoprotein E by connecting the enzyme reaction .Results and Conclusion There was no statistically significant differ-ence in the blood uric acid level in different nationality groups between the case group and the control group .Creatinine, fasting blood glucose, total cholesterol, triglycerides, and body mass index were considered risk factors of hyperuricemia . There was no statistically significant difference in apolipoprotein E genotype and allele frequency between different nationali -ties and genders in case group and control group .There might be no correlation of primary hyperuricemia and apolipoprotein E gene polymorphism .
