Relationships between CA9 and recurrence in clear cell renal carcinoma:a prelimina-ry investigation
10.7644/j.issn.1674-9960.2014.12.006
- VernacularTitle:肾透明细胞癌碳酸酐酶9表达程度与肿瘤复发关系初探
- Author:
Yipeng JIN
;
Lijun CHEN
- Publication Type:Journal Article
- Keywords:
clear cell renal carcinoma;
carbonic anhydrase 9;
prognosis;
immunohistochemistry
- From:
Military Medical Sciences
2014;(12):945-947
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of carbonic anhydrase 9(CA9) in clear cell renal carcinoma(ccRCC), and the relationship between the expression and recurrence .Methods Paraffin-embedded tissues from 53 ccRCC cases were collected during the past 3 years,and immunohistochemistry was used to detect the expression of CA 9.Fifty-three cases were followed up to evaluate the disease-free survival ( DFS) and recurrence .Association of CA9 expression with recurrence was then analyzed .Results Localized RCC recurred in eleven cases , the median DFS was 10 months, the integral optical density ( IOD) of the recurrent cases was 230 879 .84 ±64 878 .72 while the IOD of the thirteen nonrecurrent cases was much higher,444 993.31 ±146 946.27(P<0.01).Conclusion There might be a positive correlation between the low expression of CA9 and the recurrence of ccRCC .CA9 may help predict the ccRCC patients ’ prognosis.
