Advances in live attenuated vaccines by targeting host microRNAs
10.7644/j.issn.1674-9960.2014.12.017
- VernacularTitle:宿主microRNA靶向介导的减毒活疫苗研究进展
- Author:
Long LIU
;
Xiaofeng LI
;
Jie MA
;
Chengfeng QIN
- Publication Type:Journal Article
- Keywords:
live attenuated vaccine;
microRNA;
target sequence;
gene silence
- From:
Military Medical Sciences
2014;(12):990-993
- CountryChina
- Language:Chinese
-
Abstract:
Vaccine immunization represents the most effective strategy against viral infections .Antiviral vaccine candi-dates currently include live attenuated vaccine , inactivated vaccine , DNA vaccine and genetic engineering vaccine .Live at-tenuated vaccines , eliciting efficient humoral and cellular immune response by simulating natural virus infection , are clini-cally widely used.Traditionally, live attenuated vaccine strains are obtained by serial passaging in vitro or in vivo, a costly procedure accumulating random mutations .microRNA( miRNA)-targeting host gene regulation exhibits high species and tis-sue specificity .Introducing certain miRNA target sequence into viral genome by reverse genetic technique can effectively attenuate virus strains, which has great potential in vaccine design and development .In this article,attenuation strategies and progress in its application in vaccine research are disscussed .
