Relationship between the expression of Ki-67 and molecular classification and clinical patho-logical features in breast cancer
10.13315/j.cnki.cjcep.2014.11.005
- VernacularTitle:Ki-67表达与乳腺癌分子分型及临床病理特征的关系
- Author:
Ying ZHANG
;
Zhanping REN
;
Yuan ZHANG
- Publication Type:Journal Article
- Keywords:
breast neoplasm;
Ki-67;
molecular classification;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2014;(11):1220-1223
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study the expression of Ki-67 in breast cancer with different molecular classification, and to discuss the rela-tionship between the expression of Ki-67 and clinical pathological features in breast cancer. Methods All 245 patients with breast cancer were divided into different molecular classification through detecting the expression of ER, PR, HER-2 by immunohistochemical method. The expression of Ki-67 was also detected, and to study relationship between the expression and clinical pathological features. Results The difference of Ki-67 index was statistically significant in different molecular classification of breast cancer. Ki-67 index in patients with lymph node metastasis and larger tumor size were higher than that with no metastasis and smaller tumor size. Ki-67 index in patients with ER and PR positive were lower than that negative, the difference was statistically significant. Ki-67 expression differ-ence was not statistically significant between the two groups according to the median age (50 years old). But when patients were divid-ed into young and elderly groups by≤40 and≥60 years old, Ki-67 index in young group was more higher than that in elderly group. Conclusion Ki-67 index in patients with triple-negative breast cancer, young age, lymph node metastasis, larger tumor size and ER and PR negative were higher. Ki-67 can be used as an important indicator to determine breast cancer prognosis.
