Effect comparison of statins on myocardial injure and inflammatory factors in patients with unstable angina pectoris undergoing percutaneous coronary intervention
10.3969/j.issn.1671-8348.2015.06.011
- VernacularTitle:他汀类药物对 UAP 患者 PCI 术后心肌损伤与炎性因子的影响比较
- Author:
Fang PEI
;
Ji HUANG
;
Jie HUANG
;
Ying YANG
;
Changqing YU
;
Xukai WANG
- Publication Type:Journal Article
- Keywords:
angina pectoris,unstable;
percutaneous coronary intervention;
myocardial injure;
atorvastatin;
rosuvastatin
- From:
Chongqing Medicine
2015;(6):749-751
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effect of atorvastatin and rosuvastatin on myocardial injure and inflammatory factors in patients with unstable angina pectoris(UAP)undergoing percutaneous coronary intervention(PCI).Methods Ninety six UAP pa-tients undergoing PCI were enrolled in the study and divided into two groups,patients were given atorvastatin(20 mg/d)or rosuv-astatin(20 mg/d)besides conventional treatment for 1 week before PCI.Datas were collected before medication,PCI and Twenty-four hours after PCI,including CK-MB,cTnI,hs-CRP,TNF-α,IL-6 and IL-10.Results Twenty-four hours after surgery,the PCI, CK-MB,cTnI,hs-CRP,TNF-α,IL-6 of rosuvastatin group were lower than those of atorvastatin group(P <0.05),but IL-10 of ro-suvastatin group was higher than that of atorvastatin group(P <0.05).Conclusion Rosuvastatin (20 mg/d)is better than atorvas-tatin (20 mg/d)in the efficacy of UAP patients undergoing PCI,which can reduce the level of myocardial injure and inflammatory factors effectively.
